Ketamine Research

1.) Retrospective study of off-label at-home sublingual ketamine use in 664 patients studying effects on depression/anxiety https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767816/

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2.) "At-home, sublingual ketamine telehealth is a safe and effective treatment for moderate to severe anxiety and depression" https://www.sciencedirect.com/science/article/pii/S0165032722007625

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3.) Ketamine for the treatment of mental health and substance use disorders: comprehensive systematic review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715255/

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4.) Meta-analysis of twenty-eight studies demonstrating acute efficacy of sub anesthetic ketamine. https://www.sciencedirect.com/science/article/abs/pii/S0165032720327026

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5.) Randomized controlled trial in 30 individuals with PTSD using IV ketamine vs midazolam control showing 67% response vs. 20% in control https://pubmed.ncbi.nlm.nih.gov/33397139/

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6.) Open label study with 3 months of weekly subcutaneous ketamine at 1 mg/kg in 20 patients with txt resistant GAD and SAD. https://pubmed.ncbi.nlm.nih.gov/29561204/

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7.) IV ketamine 0.5 mg/kg on depressive/anxiety features in 25 males with severe depression. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767816/

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*It should be noted that many current studies do have smaller sample sizes and some of the studies listed do use alternative routes of ketamine administration which may have impact on outcome of studies when comparing to sublingual administration